Stein Murray B, Höfler Michael, Perkonigg Axel, Lieb Roselind, Pfister Hildegard, Maercker Andreas, Wittchen Hans-Ulrich
Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA.
Int J Methods Psychiatr Res. 2002;11(4):143-53. doi: 10.1002/mpr.132.
Individual differences are thought to influence the propensity for exposure to trauma and the subsequent development of post-traumatic stress disorder (PTSD) symptoms. Prior research has identified pre-existing mood disorders as one such individual risk factor for traumatic events as well as for PTSD. The present study reports the incidence of traumatic events (and PTSD) and examines psychiatric risk factors for trauma exposure in a prospective community sample. Data come from a prospective, longitudinal epidemiological study of adolescents and young adults (age 14-24) in Munich, Germany. Respondent diagnoses (N = 2,548) at baseline and at follow-up 34-50 months later were considered. Psychiatric diagnoses at baseline were examined as predictors of qualifying trauma. Baseline prevalence of persons having experienced trauma meeting DSM-IV A1 and A2 criteria ('qualifying trauma') was 16.7%; during the follow-up period, 20.3% persons had experienced incident (new) qualifying traumata. The prevalence of PTSD, including subthreshold cases, at baseline was 5.6%; by the end of the follow-up period this had increased to 10.3%. Presence of an anxiety disorder at baseline predicted exposure to qualifying traumas during the follow-up period (adjusted ORs ranging from 1.36 for any trauma type to 3.00 for sexual trauma); this association was apparently due to an increased tendency to report events as being particularly horrific (meeting A2 criteria). In contrast, presence of illicit drug use predicted the onset of traumatic events (specifically assaultive and sexual trauma) meeting at least A1 criteria, suggesting an actual exposure to these types of traumatic events for this class of disorders. In this prospective study of urban adolescents and young adults, certain classes of pre-existing psychiatric disorders (most notably anxiety disorders and illicit drug use disorders) were associated with increased risk for qualifying traumatic events. The mechanisms by which premorbid psychiatric disorders promote exposure to traumatic events are unknown. Better understanding of these pathways may lead to novel strategies for primary and secondary prevention of PTSD.
个体差异被认为会影响遭受创伤的倾向以及创伤后应激障碍(PTSD)症状的后续发展。先前的研究已将既存的情绪障碍确定为创伤性事件以及PTSD的一种个体风险因素。本研究报告了创伤性事件(和PTSD)的发生率,并在一个前瞻性社区样本中检查了创伤暴露的精神风险因素。数据来自德国慕尼黑对青少年和青年成年人(年龄14 - 24岁)进行的一项前瞻性纵向流行病学研究。考虑了基线时和34 - 50个月后的随访时的受访者诊断(N = 2548)。将基线时的精神诊断作为符合条件创伤的预测因素进行检查。经历符合《精神疾病诊断与统计手册》第四版A1和A2标准的创伤(“符合条件的创伤”)的人群基线患病率为16.7%;在随访期间,20.3%的人经历了事件性(新的)符合条件的创伤。基线时PTSD的患病率,包括亚阈值病例,为5.6%;到随访期结束时,这一患病率已增至10.3%。基线时存在焦虑障碍可预测随访期间暴露于符合条件的创伤(调整后的比值比范围从任何创伤类型的1.36到性创伤的3.00);这种关联显然是由于将事件报告为特别可怕(符合A2标准)的倾向增加。相比之下,使用非法药物可预测符合至少A1标准的创伤性事件(特别是攻击性和性创伤)的发生,这表明这类疾病的患者实际暴露于这些类型的创伤性事件。在这项针对城市青少年和青年成年人的前瞻性研究中,某些既存的精神疾病类别(最显著的是焦虑障碍和非法药物使用障碍)与符合条件的创伤性事件风险增加相关。病前精神疾病促进创伤性事件暴露的机制尚不清楚。对这些途径的更好理解可能会带来PTSD一级和二级预防的新策略。