在肝脏储存和清除动态过程中，蔗糖刺激FITC-葡聚糖释放到胆汁中。

Sucrose-stimulated release of FITC-dextran into the bile in the dynamics of its storage and elimination from the liver.

作者信息

Pupyshev A B, Maiborodina V I

机构信息

Central Research Laboratory, Novosibirsk State Medical Academy.

出版信息

Bull Exp Biol Med. 2002 Aug;134(2):139-44. doi: 10.1023/a:1021128029648.

DOI:10.1023/a:1021128029648

PMID:12459835

Abstract

Stimulation of release of FITC-dextran endocytosed in the liver by an injection of hypertonic sucrose led to the appearance of a less pronounced and prolonged peak (with the maximum at min 15-25) at later terms after injection of the marker (30 days). Biliary release of FITC-dextran was 4-9-fold accelerated on days 1-14 in comparison with the constitutive release, and after 30 days it was accelerated 19-fold, which reflects high capacity of the long storage compartment to stimulated release of FITC-dextran into the bile.

摘要

注射高渗蔗糖刺激肝脏内吞的异硫氰酸荧光素标记葡聚糖（FITC - dextran）释放，导致在注射标记物30天后的较晚时间出现一个不太明显且持续时间较长的峰值（最大值出现在第15 - 25分钟）。与组成型释放相比，FITC - dextran在第1 - 14天的胆汁释放加速了4 - 9倍，30天后加速了19倍，这反映了长期储存隔室将FITC - dextran刺激释放到胆汁中的能力较高。