Berlit P, Steinbrecher A
Neurologische Klinik Alfried Krupp Krankenhaus Essen.
Fortschr Neurol Psychiatr. 2002 Dec;70(12):663-77. doi: 10.1055/s-2002-35855.
This review focuses on isolated CNS-angiitis and cerebral involvement in systemic vasculitides and collagen vascular diseases. CNS-vasculitis presents with headache, multifocal symptoms, and encephalopathy, respectively. Clinical diagnosis is based on MRI, angiography and both CSF and serum examinations. But neither laboratory nor neuroradiological findings are specific - in all vasculitides with the exception of the Behçet-syndrome a biopsy is necessary before immunosuppressive treatment is started. Therapy of choice is the combination of corticosteroids and cyclophosphamide.
本综述聚焦于孤立性中枢神经系统血管炎以及系统性血管炎和胶原血管病中的脑部受累情况。中枢神经系统血管炎分别表现为头痛、多灶性症状和脑病。临床诊断基于磁共振成像(MRI)、血管造影以及脑脊液和血清检查。但实验室检查结果和神经放射学检查结果均不具有特异性——除白塞综合征外,在所有血管炎中,开始免疫抑制治疗前均需进行活检。首选治疗方法是皮质类固醇和环磷酰胺联合使用。