英国海湾战争退伍军人骨形成减少：一项骨组织形态计量学研究。
Reduced bone formation in UK Gulf War veterans: a bone histomorphometric study.
作者信息
Compston J E, Vedi S, Stephen A B, Bord S, Lyons A R, Hodges S J, Scammell B E
机构信息
Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 2QQ, UK.
出版信息
J Clin Pathol. 2002 Dec;55(12):897-9. doi: 10.1136/jcp.55.12.897.
AIMS
Gulf War veterans report a high prevalence of musculoskeletal symptoms. The aim of this study was to establish whether there were abnormalities in bone turnover and remodelling in a group of symptomatic subjects who had served in the Gulf War.
METHODS
Iliac crest bone biopsies were obtained from 17 Gulf War veterans who were seeking litigation and compared with those of 13 age and sex matched healthy controls. Bone histomorphometry was performed using image analysis.
RESULTS
Cancellous bone area was significantly lower in Gulf War veterans than in control subjects (p = 0.027) and this was associated with a significantly reduced mineral apposition rate (p = 0.002), mean wall width (p < 0.0001), and bone formation rate at the tissue level (p < 0.0001).
CONCLUSIONS
These results demonstrate that in this group of Gulf War veterans there was a significant reduction in bone formation at both the cellular and tissue level and this was associated with a reduction in cancellous bone area. The cause of these abnormalities is unknown but might be related to potentially harmful exposures during service in the Gulf War or to changes in life style as a result of chronic ill health. The clinical relevance of the observed reduction in bone formation remains to be established.
目的
海湾战争退伍军人报告肌肉骨骼症状的患病率很高。本研究的目的是确定一组有症状的曾参加海湾战争的受试者是否存在骨转换和重塑异常。
方法
从17名寻求诉讼的海湾战争退伍军人身上获取髂嵴骨活检样本，并与13名年龄和性别匹配的健康对照者的样本进行比较。使用图像分析进行骨组织形态计量学研究。
结果
海湾战争退伍军人的松质骨面积显著低于对照受试者（p = 0.027），这与矿物质沉积率显著降低（p = 0.002）、平均壁宽（p < 0.0001）以及组织水平的骨形成率（p < 0.0001）相关。
结论
这些结果表明，在这组海湾战争退伍军人中，细胞水平和组织水平的骨形成均显著减少，且这与松质骨面积减少有关。这些异常的原因尚不清楚，但可能与海湾战争服役期间潜在的有害暴露有关，或者与慢性健康问题导致的生活方式改变有关。所观察到的骨形成减少的临床相关性仍有待确定。
Zotero 插件