甲状腺滤泡性肿瘤及肿瘤样病变包膜中高分子量钙调蛋白阳性的基质细胞
High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions.
作者信息
Nakayama H, Enzan H, Miyazaki E, Moriki T, Kiyoku H, Toi M, Kuroda N, Hiroi M
机构信息
First Department of Pathology, Kochi Medical School, Nankoku-city, Kochi 783-8505, Japan.
出版信息
J Clin Pathol. 2002 Dec;55(12):917-20. doi: 10.1136/jcp.55.12.917.
AIMS
To investigate the smooth muscle nature of the spindle stromal cells in the capsule of thyroid tumours and tumour-like lesions.
METHODS
Immunostaining for high molecular weight caldesmon (HCD), a highly specific marker for smooth muscle differentiation, was performed in 70 primary thyroid tumours and tumour-like lesions (21 hyperplastic nodules, 29 follicular adenomas, five minimally invasive follicular carcinomas, six widely invasive follicular carcinomas, and nine encapsulated papillary carcinomas).
RESULTS
HCD positive stromal cells (HCD+ cells) were detected in the capsule of 20 of the 21 hyperplastic nodules, and all of the 29 follicular adenomas and five minimally invasive follicular carcinomas, whereas HCD+ cells were seen in the capsule of only four of the six widely invasive follicular carcinomas and no HCD+ cells were seen in the capsule of the nine encapsulated papillary carcinomas examined.
CONCLUSIONS
The presence of HCD+ cells in the capsule is characteristic of thyroid follicular tumours and tumour-like lesions. The stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions are different from those of encapsulated papillary carcinoma.
目的
研究甲状腺肿瘤及肿瘤样病变包膜中梭形基质细胞的平滑肌性质。
方法
对70例原发性甲状腺肿瘤及肿瘤样病变（21例增生性结节、29例滤泡性腺瘤、5例微侵袭性滤泡癌、6例广泛侵袭性滤泡癌和9例包膜型乳头状癌）进行高分子量钙调蛋白（HCD）免疫染色，HCD是平滑肌分化的高度特异性标志物。
结果
在21例增生性结节中的20例、29例滤泡性腺瘤及5例微侵袭性滤泡癌的包膜中检测到HCD阳性基质细胞（HCD+细胞），而在6例广泛侵袭性滤泡癌中仅4例的包膜中可见HCD+细胞，在所检查的9例包膜型乳头状癌的包膜中未见到HCD+细胞。
结论
包膜中存在HCD+细胞是甲状腺滤泡性肿瘤及肿瘤样病变的特征。甲状腺滤泡性肿瘤及肿瘤样病变包膜中的基质细胞与包膜型乳头状癌的不同。
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