Nakayama H, Enzan H, Yamamoto M, Miyazaki E, Yasui W
Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8551, Japan.
J Clin Pathol. 2004 Jul;57(7):776-7. doi: 10.1136/jcp.2004.016279.
To investigate the smooth muscle nature of the stromal cells in the capsule of hepatocellular carcinomas.
Immunohistochemical analysis using monoclonal antibody to high molecular weight caldesmon (HCD), a highly specific marker for smooth muscle cells, was performed in 33 encapsulated hepatocellular carcinomas and adjacent hepatic tissues.
HCD positive stromal cells were detected in the capsule of 21 of the 33 hepatocellular carcinomas examined.
The capsule of hepatocellular carcinomas contains smooth muscle cells.
研究肝细胞癌包膜中基质细胞的平滑肌性质。
使用针对高分子量钙调蛋白(HCD)的单克隆抗体进行免疫组织化学分析,HCD是平滑肌细胞的高度特异性标志物,对33例有包膜的肝细胞癌及相邻肝组织进行检测。
在所检测的33例肝细胞癌中,21例癌组织的包膜中检测到HCD阳性基质细胞。
肝细胞癌的包膜含有平滑肌细胞。