Barnhorst D A, Oxman H A, Connolly D C, Pluth J R, Danielson G K, Wallace R B, McGoon D C
J Thorac Cardiovasc Surg. 1976 Feb;71(2):230-7.
Isolated mitral valve replacement with the Starr-Edwards prosthesis has been performed on 657 patients at the Mayo Clinic during the 11 year period ending January, 1972. The most recent subset of that series comprised patients who received the Model 6120 prosthesis. In this group, the operative mortality rate was 9 per cent and the actuarial late death rate at 5 years was 20 per cent. This survival rate is a significant improvement over the natural history of severe mitral valve disease. Factors associated with operative deaths are large left artrial size, advanced functional class, and previous heart surgery. Variables associated with higher incidence of late deaths are large left atrial size, patient age at operation, and multivalve disease. Risk of thromboembolism is increased with large left atrial size, presence of left atrial thrombus, and inadequate anticoagulant therapy.
截至1972年1月的11年间，梅奥诊所对657例患者实施了采用斯塔尔-爱德华兹人工瓣膜的单纯二尖瓣置换术。该系列中最新的一组患者接受的是6120型人工瓣膜。在这组患者中，手术死亡率为9%，5年的精算晚期死亡率为20%。与严重二尖瓣疾病的自然病程相比，这一生存率有显著提高。与手术死亡相关的因素包括左心房大、心功能分级高和既往心脏手术史。与晚期死亡发生率较高相关的变量包括左心房大、手术时患者年龄和多瓣膜疾病。左心房大、存在左心房血栓以及抗凝治疗不足会增加血栓栓塞风险。
