Worby Carolyn A, Dixon Jack E
Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
Nat Rev Mol Cell Biol. 2002 Dec;3(12):919-31. doi: 10.1038/nrm974.
Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif - the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in membrane trafficking and protein sorting. It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking.
分选连接蛋白是一类多样的细胞运输蛋白，它们因存在磷脂结合基序——PX结构域而被归为一类。这些蛋白结合特定磷脂的能力，以及它们形成蛋白质-蛋白质复合物的倾向，表明这些蛋白在膜运输和蛋白质分选过程中发挥作用。确定各种分选连接蛋白在蛋白质运输中具有特定作用还是普遍作用将是一件有趣的事情。
