Blasi Francesco, Carmeliet Peter
Department of Molecular Biology and Functional Genomics, DIBIT, Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy.
Nat Rev Mol Cell Biol. 2002 Dec;3(12):932-43. doi: 10.1038/nrm977.
The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.
纤溶酶原系统与血栓溶解、伤口愈合、组织再生、癌症以及许多其他影响健康和疾病的过程有关。尿激酶受体uPAR最初被认为有助于迁移细胞的定向侵袭，但现在越来越明显的是，这种蛋白酶受体以非蛋白水解的方式引发了大量细胞反应，包括细胞黏附、分化、增殖和迁移。
