Feldman J M, Plonk J W
Metabolism. 1976 Jan;25(1):97-103. doi: 10.1016/0026-0495(76)90164-5.
We evaluated the effect of intravenous (i.v.) glucose on the plasma tryptophan (TRP) and tyrosine (TYR) concentration of 12 normal subjects, six patients with carcinoid tumors and the carcinoid syndrome (carcinoid syndrome), and five patients with carcinoid tumors without the carcinoid syndrome (tumor.) Following i.v. glucose administration, the plasma Trp concentration of the normal subjects and the tumor patients incresed, while the plasma Trp concentration of the carcinoid syndrome patients decreased. Following i.v. glucose administration, the plasma Tyr concentration of the normal subjects and the tumor patients decreased, while the plasma Tyr concentration of the carcinoid syndrome patients did not change. The response to i.v. insulin differed in some respects from the response to i.v. glucose: the plasma Trp of normal subjects did not change while the plasma Trp of carcinoid syndrome patients decreased; the plasma Tyr of the normal subjects increased while the plasma Tyr concentration of the carcinoid syndrome patients did not change. The carcinoid syndrome patients had high serum serotonin concentrations and impaired glucose tolerance and insulin secretion as compared to both normal subjects and tumor patients. We conclude that under appropriate experimental conditions, glucose administration can increase the plasma Trp concentration of normal human subjects.
我们评估了静脉注射葡萄糖对12名正常受试者、6名患有类癌瘤和类癌综合征的患者以及5名患有类癌瘤但无类癌综合征的患者（肿瘤患者）血浆色氨酸（TRP）和酪氨酸（TYR）浓度的影响。静脉注射葡萄糖后，正常受试者和肿瘤患者的血浆色氨酸浓度升高，而类癌综合征患者的血浆色氨酸浓度降低。静脉注射葡萄糖后，正常受试者和肿瘤患者的血浆酪氨酸浓度降低，而类癌综合征患者的血浆酪氨酸浓度没有变化。静脉注射胰岛素后的反应在某些方面与静脉注射葡萄糖后的反应不同：正常受试者的血浆色氨酸没有变化，而类癌综合征患者的血浆色氨酸降低；正常受试者的血浆酪氨酸升高，而类癌综合征患者的血浆酪氨酸浓度没有变化。与正常受试者和肿瘤患者相比，类癌综合征患者的血清5-羟色胺浓度较高，葡萄糖耐量和胰岛素分泌受损。我们得出结论，在适当的实验条件下，给予葡萄糖可以增加正常人体受试者的血浆色氨酸浓度。
