结核病结构基因组学联盟：为药物研发提供结构基础。
The TB structural genomics consortium: providing a structural foundation for drug discovery.
作者信息
Goulding Celia W, Apostol Marcin, Anderson Daniel H, Gill Harindarpal S, Smith Clare V, Kuo Mack R, Yang Jin Kuk, Waldo Geoffrey S, Suh Se Won, Chauhan Radha, Kale Avinash, Bachhawat Nandita, Mande Shekhar C, Johnston Jodie M, Lott J Shaun, Baker Edward N, Arcus Vickery L, Leys David, McLean Kirsty J, Munro Andrew W, Berendzen Joel, Sharma Vivek, Park Min S, Eisenberg David, Sacchettini James, Alber Tom, Rupp Bernhard, Jacobs William, Terwilliger Thomas C
机构信息
Bioscience Division, Mail Stop M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
出版信息
Curr Drug Targets Infect Disord. 2002 Jun;2(2):121-41. doi: 10.2174/1568005023342551.
Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.
结构基因组学，即蛋白质结构的大规模测定，有望为药物研发提供广泛的结构基础。结核病结构基因组学联盟致力于鼓励、协调并推动结核分枝杆菌蛋白质结构的测定工作，并希望在5年内测定400种结核蛋白的结构。该联盟迄今已测定了28种结核蛋白的结构。这些蛋白结构已为药物研发工作奠定了基础。
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