Gerber E, Koch P
Med Klin. 1976 Jan 9;71(2):51-5.
In 10 women taking 0.5 mg lynestrenol for oral contraception endometrium biopsies were carried out in several consecutive cycles between the 21st and 25th day of each cycle. In addition pregnandiol excretion in the urine was measured in one of the last three treatment cycles always on the 10th and 21st day of cycle. During treatment of a characteristic, monomorphic microscopical endometrium picture was observed with hardly distinct endometrium glands and only slight decidualike transformation of cellular elements of the stroma. From these histological pictures it is concluded that oral application of 0,5 mg lynestrenol produces endometrium changes characterized by insufficient transformation so that nidation of a blastocyte becomes impossible.
在10名口服0.5毫克炔雌醇用作避孕的女性中，在每个周期的第21天至25天之间的几个连续周期进行了子宫内膜活检。此外，在最后三个治疗周期中的一个周期里，总是在周期的第10天和第21天测量尿中孕二醇的排泄量。在治疗期间，观察到一种特征性的、单形性的显微镜下子宫内膜图像，子宫内膜腺体几乎不明显，基质细胞成分仅有轻微的蜕膜样转化。从这些组织学图像可以得出结论，口服0.5毫克炔雌醇会引起子宫内膜变化，其特征是转化不足，从而使胚泡着床变得不可能。
