用烷基化剂处理大鼠后，其尿中核酸和烟酰胺衍生物的排泄增加。
Increased urinary excretion of nucleic acid and nicotinamide derivatives by rats after treatment with alkylating agents.
作者信息
Chu B C, Lawley P D
出版信息
Chem Biol Interact. 1975 May;10(5):333-8. doi: 10.1016/0009-2797(75)90054-x.
Rats treated with di(2-chloroethyl)methylamine (HN2), N-methyl-N-nitrosourea (MNUA) and N-ethyl-N-nitrosourea (ENUA) excrete significantly larger amounts of deoxycytidine (dC) and thymidine in their urine 0-24 h after treatment. Ethyl methanesulphonate (EMS) and dimethylnitrosamine (DMN) gave negative results in this respect but all five alkylating agents increased the excretion of 1-methyl-nicotinamide (1-meNmd). In addition, a larger quantity of 7-methylguanine (7MG) and uric acid was excreted after DMN treatment. 1,4-Dimethanesulphonoxybutane (myleran), 2,2-dichlorovinyl dimethyl phosphate (dichlorvos), 5-fluorouracil (5FU), cytosine arabinoside (araC), 2-acetylaminofluorene (AAF) and 7-bromomethylbenz-[a]anthracene (7-BrMBA) gave negative results.
用二（2-氯乙基）甲胺（HN2）、N-甲基-N-亚硝基脲（MNUA）和N-乙基-N-亚硝基脲（ENUA）处理的大鼠在处理后0 - 24小时尿液中排出的脱氧胞苷（dC）和胸苷量显著增加。甲磺酸乙酯（EMS）和二甲基亚硝胺（DMN）在这方面呈阴性结果，但所有五种烷化剂均增加了1-甲基烟酰胺（1-meNmd）的排泄量。此外，DMN处理后排出的7-甲基鸟嘌呤（7MG）和尿酸量更多。1,4-二甲磺酸丁酯（马利兰）、2,2-二氯乙烯基二甲基磷酸酯（敌敌畏）、5-氟尿嘧啶（5FU）、阿糖胞苷（araC）、2-乙酰氨基芴（AAF）和7-溴甲基苯并[a]蒽（7-BrMBA）呈阴性结果。
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