Cannavo Dominick
Department of Anesthesia, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA.
Am J Orthop (Belle Mead NJ). 2002 Nov;31(11 Suppl):21-3.
It has become increasingly well documented that, compared with general anesthesia, neuraxial anesthesia reduces the risk of venous thromboembolism after joint replacement surgery. The concurrent use of anticoagulants with neuraxial anesthesia, however, has raised some safety concerns. Recent large-scale, prospective, randomized experience indicates that the selective factor Xa inhibitor fondaparinux does not increase the risk of epidural hematoma when used in combination with neuraxial anesthesia.
越来越多的文献证明，与全身麻醉相比，神经轴索麻醉可降低关节置换手术后静脉血栓栓塞的风险。然而，抗凝剂与神经轴索麻醉同时使用引发了一些安全问题。最近大规模、前瞻性、随机试验表明，选择性Xa因子抑制剂磺达肝癸钠与神经轴索麻醉联合使用时不会增加硬膜外血肿的风险。
