DiSaia P J, Morrow C P, Haverback B J, Dyce B J
Obstet Gynecol. 1976 Jan;47(1):95-9.
Serial carcinoembryonic antigen (CEA) assays were performed on 10 patients with primary invasive squamous cell carcinoma of the cervix, 7 patients with recurrent squamous cell carcinoma of the cervix, and 5 patients with invasive squamous carcinoma of the vulva. Plasma CEA determinations were accomplished by radioimmunoassay, using a modification of Hanson's method. In 8 of the 10 patients with invasive squamous cell carcinoma of the cervix, positive CEA values dropped to normal ranges during the course of radiotherapy, usually in the first 4 weeks of treatment. A similar decrease in patients' serum values was seen after surgical extirpation of recurrent squamous cell carcinoma of the cervix by pelvic exenteration. Serum values also dropped to within normal limits in a limited number of patients with squamous cell carcinoma of the vulva after complete removal of all gross disease. Persistence of disease was associated with all gross disease. Persistence of disease was associated with chronically elevated values. A suggestion is made that patients with elevated CEA values may be followed with serial determinations to substantiate complete eradication of their disease.
对10例原发性宫颈浸润性鳞状细胞癌患者、7例复发性宫颈鳞状细胞癌患者和5例外阴浸润性鳞状细胞癌患者进行了癌胚抗原（CEA）系列检测。血浆CEA测定采用放射免疫分析法，对汉森方法进行了改进。10例宫颈浸润性鳞状细胞癌患者中有8例，其CEA阳性值在放疗过程中，通常在治疗的前4周降至正常范围。通过盆腔脏器清除术手术切除复发性宫颈鳞状细胞癌后，患者血清值也出现了类似下降。在完全切除所有肉眼可见病变后，少数外阴鳞状细胞癌患者的血清值也降至正常范围内。疾病持续存在与所有肉眼可见病变相关。疾病持续存在与CEA值长期升高相关。有人建议，对于CEA值升高的患者，可通过系列检测进行随访，以证实其疾病已被彻底根除。
