Mrowietz U
Department of Dermatology, University of Kiel, Germany.
Clin Exp Dermatol. 2002 Oct;27(7):591-6. doi: 10.1046/j.1365-2230.2002.01171.x.
Expression of a variety of surface epitopes is a characteristic feature of immune cells. Receptors and adhesion molecules are the most predominant ones. It is also characteristic that epitope expression is modulated during cellular activation. In inflammatory skin diseases these structures can be used to define not only the type of cell but also their activity status. The availability of monoclonal antibodies and fusion proteins enabled to target cellular surface epitopes in order to modulate the cellular function as a principle of treatment. In psoriasis receptor-targeted therapy has been developed and tested in a considerable number of clinical trials. However, these approaches revealed that not all the strategies are equally effective. In this review the development of receptor-targeted treatment for skin disorders, mainly psoriasis, is described. Clinical as well as experimental data obtained with the various compounds employed are discussed with regard to clinical efficacy, safety and tolerability.
多种表面表位的表达是免疫细胞的一个特征。受体和黏附分子是最主要的表位。表位表达在细胞活化过程中受到调节也是其特征之一。在炎症性皮肤病中，这些结构不仅可用于定义细胞类型，还可用于定义其活性状态。单克隆抗体和融合蛋白的可用性使得以细胞表面表位为靶点来调节细胞功能成为一种治疗原则。在银屑病中，已经开发出受体靶向疗法并在大量临床试验中进行了测试。然而，这些方法表明并非所有策略都同样有效。在这篇综述中，描述了针对皮肤疾病（主要是银屑病）的受体靶向治疗的发展。就临床疗效、安全性和耐受性而言，讨论了使用各种化合物获得的临床和实验数据。
