溶液中小角散射结构分析的进展
Advances in structure analysis using small-angle scattering in solution.
作者信息
Svergun Dmitri I, Koch Michel H J
机构信息
EMBL, Hamburg Outstation, Notkestrasse 85, D-22603 Hamburg, Germany.
出版信息
Curr Opin Struct Biol. 2002 Oct;12(5):654-60. doi: 10.1016/s0959-440x(02)00363-9.
Abstract
The resolution and reliability of solution scattering models have been significantly improved by ab initio shape and domain structure determination, and by detailed modelling of macromolecular complexes using rigid-body refinement. Substantial progress has also been made in the quantitative analysis and modelling of assembly and folding processes, and intermolecular interactions.
摘要
通过从头开始确定形状和结构域结构，以及使用刚体精修对大分子复合物进行详细建模，溶液散射模型的分辨率和可靠性得到了显著提高。在组装和折叠过程以及分子间相互作用的定量分析和建模方面也取得了实质性进展。
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