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Re: Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor.

作者信息

Morison Ian M, Becroft David M O, Reeve Anthony E

出版信息

J Natl Cancer Inst. 2002 Dec 4;94(23):1809; author reply 1809-10. doi: 10.1093/jnci/94.23.1809.

DOI:10.1093/jnci/94.23.1809
PMID:12464656
Abstract
摘要

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1
Re: Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor.回复:胰岛素样生长因子-II(IGF2)基因印记缺失在鉴别肾母细胞瘤特定生物学亚型中的作用
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Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor.胰岛素样生长因子-II(IGF2)基因印记缺失在鉴别肾母细胞瘤特定生物学亚型中的作用
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Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity.肾母细胞瘤中胰岛素样生长因子-II基因表达增加并不依赖于基因组印记缺失或杂合性缺失。
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Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis.H19是一个印记且假定的肿瘤抑制基因,其失活是肾母细胞瘤发生过程中的一个肿瘤前事件。
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Loss of imprinting of the IGF2 gene in a Wilms' tumor in an adult.一名成年患者肾母细胞瘤中IGF2基因印记缺失
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Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor.11号染色体缺失、12号染色体三体以及可能的16号染色体缺失与肾母细胞瘤中胰岛素样生长因子-II印记缺失的关联。
Genes Chromosomes Cancer. 2006 Jun;45(6):592-601. doi: 10.1002/gcc.20321.
7
Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour.胰岛素样生长因子2(IGF2)印记缺失与肾母细胞瘤中H19的表达降低及异常甲基化有关。
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Role of genomic imprinting in Wilms' tumour and overgrowth disorders.基因组印记在肾母细胞瘤和过度生长疾病中的作用。
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Association of chromosome arm 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor.肾母细胞瘤中16号染色体长臂缺失与胰岛素样生长因子-II印记缺失的关联
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