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系统性硬化症患者皮肤切片中真皮成纤维细胞内转化生长因子-β受体的表达上调。

Upregulated expression of transforming growth factor-beta receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis.

作者信息

Kubo Masahide, Ihn Hironobu, Yamane Kenichi, Tamaki Kunihiko

机构信息

Faculty of Medicine, University of Tokyo, Japan.

出版信息

J Rheumatol. 2002 Dec;29(12):2558-64.

PMID:12465152
Abstract

OBJECTIVE

To investigate the expression levels of transforming growth factor-beta (TGF-beta) receptors in the skin of patients with systemic sclerosis (SSc).

METHOD

We examined expressions of TGF-beta type I and type II receptors (TGF-betaRI and TGF-betaRII) in skin sections of 5 patients with SSc and 5 healthy controls using in situ hybridization and immunohistochemical analysis.

RESULTS

The expression levels of both TGF-betaRI and TGF-betaRII were elevated in the dermal fibroblasts of skin sections from patients with SSc in comparison to control skin sections in in situ hybridization and in immunohistochemical stainings. The numbers of fibroblasts expressing TGF-betaRI and TGF-betaRII in the SSc skin sections were increased in comparison to controls. The inflammatory cells around the vessels also expressed TGF-betaRI and TGF-betaRII intensively in the SSc skin sections.

CONCLUSION

These results suggest that the autocrine TGF-beta signaling due to the overexpression of TGF-betaRI and TGF-betaRII in dermal fibroblasts is involved in the pathogenesis of dermal fibrosis in patients with SSc.

摘要

目的

研究系统性硬化症（SSc）患者皮肤中转化生长因子-β（TGF-β）受体的表达水平。

方法

我们采用原位杂交和免疫组化分析，检测了5例SSc患者和5例健康对照者皮肤切片中TGF-βⅠ型和Ⅱ型受体（TGF-βRI和TGF-βRII）的表达。

结果

在原位杂交和免疫组化染色中，与对照皮肤切片相比，SSc患者皮肤切片的真皮成纤维细胞中TGF-βRI和TGF-βRII的表达水平均升高。与对照组相比，SSc皮肤切片中表达TGF-βRI和TGF-βRII的成纤维细胞数量增加。SSc皮肤切片中血管周围的炎症细胞也强烈表达TGF-βRI和TGF-βRII。

结论

这些结果表明，真皮成纤维细胞中TGF-βRI和TGF-βRII的过度表达导致的自分泌TGF-β信号传导参与了SSc患者真皮纤维化的发病机制。

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