Minamoto Toshinari, Ougolkov Andrei V, Mai Masayoshi
Division of Diagnostic Molecular Oncology, Cancer Research Institute, Kanazawa University, 13-1, Takara-machi, Kanazawa 920-0934, Japan.
Expert Rev Mol Diagn. 2002 Nov;2(6):565-75. doi: 10.1586/14737159.2.6.565.
Releasing individuals from susceptibility to and anxiety about the development of cancer is an eventual goal of cancer research. This owes much to rapid progress in molecular oncology that is supported by advances in technology. Cancers of the colon and rectum, pancreas and lung that share certain clinical and molecular oncological characteristics represent timely and important target of this field. Of the genes altered in these types of cancers, the best documented is K-ras. Currently highlighted along with this oncogene is beta-catenin, which has roles in both cell adhesion and transformation. Molecular diagnosis and susceptibility assessment targeting of such oncogenes will be promising for improvement in treatment and prevention of cancer, thereby contributing to human healthcare. Here we review recent knowledge on molecular diagnosis of sporadic cancers, with focus on K-ras and beta-catenin oncogenes.
使个体摆脱对癌症发生的易感性和焦虑是癌症研究的最终目标。这在很大程度上归功于分子肿瘤学的快速进展，而这又得益于技术的进步。具有某些临床和分子肿瘤学特征的结肠癌、直肠癌、胰腺癌和肺癌是该领域及时且重要的研究靶点。在这些类型的癌症中发生改变的基因中，研究最充分的是K-ras。目前与这种癌基因一起受到关注的是β-连环蛋白，它在细胞黏附和转化中都发挥作用。针对此类癌基因的分子诊断和易感性评估对于改善癌症的治疗和预防具有广阔前景，从而有助于人类医疗保健。在此，我们综述散发性癌症分子诊断的最新知识，重点关注K-ras和β-连环蛋白癌基因。
