Roy I
Center for Bioethics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Somat Cell Mol Genet. 2001 Nov;26(1-6):175-91. doi: 10.1023/a:1021086915922.
This chapter will outline the various concerns which have been raised in scientific, bioethics, and lay communities about the use of lentiviral vectors for purposes of gene therapy. Many of these concerns are ranged around gene therapy itself; others are concerns particular to using this sort of vector for genetic modification of human cells. These concerns are outlined within the chapter, and arguments are given in favor and against various approaches to these concerns. Lastly, it is noted throughout that at this stage of research into gene therapy, the most practical approach to these dilemmas is to maintain awareness of the ethical problems and provide information to those concerned with all aspects of the development of this set of technologies.
本章将概述科学界、生物伦理学界以及普通大众针对将慢病毒载体用于基因治疗目的所提出的各种担忧。其中许多担忧围绕基因治疗本身；其他则是关于使用这类载体对人类细胞进行基因改造的特定担忧。本章将对这些担忧进行概述，并给出支持和反对针对这些担忧的各种处理方法的论据。最后，需要指出的是，在基因治疗的现阶段研究中，应对这些困境最切实可行的方法是保持对伦理问题的认识，并向关注这一系列技术发展各个方面的人士提供相关信息。
