Vantrappen G, Tack J, Huyberechts G, Sifrim D, Geboes K, Janmsens J, Van Overstraeten R
Center for Gastroenterological Research and Dept. of Pathology, University Hospital Gasthuisberg and Interuniversity Micro Electronics Centre, University of Leuven, Leuven, Belgium.
Scand J Gastroenterol. 2002 Nov;37(11):1253-8. doi: 10.1080/003655202761020506.
In vitro studies of a recently developed acid exposure sensor show that the sensor response (SR) to acid <pH 4 is linearly determined by the duration and degree of acidity. The aim was to determine whether SR correlates with the severity of acid-induced esophageal mucosal lesions and acid-induced heartburn.
HCl pH 1.5 or saline was infused into the feline esophagus for 5-20 min. Simultaneously, sensor measurements were performed below the infusion port. The histological damage was scored by an independent pathologist. In 15 normal subjects, HCl pH 1 was infused into the esophagus and the severity of the heartburn (0-5) was scored at 5-min intervals. In 10 subjects who experienced heartburn during acid perfusion, initial perfusion with HCl was repeated during heartburn induction time minus 5 min, followed by perfusion with the subject's own gastric juice, titrated to pH 2; heartburn severity was again scored at 5-min intervals. Acid exposure sensors positioned below the infusion port were removed at heartburn scores 1, 2 and 3.
A good correlation was found between SR and the histological score for mucosal damage in the cat esophagus (r = 0.64, P < 0.005). There was a good relation between heartburn severity score and acid exposure time (r = 0.84, P < 0.001), and a significant but weaker relation between heartburn severity and SR.
In cats, there is a good relation between the severity of acid-induced esophageal mucosal lesions and SR. In men, there is a significant correlation between the severity of acid-induced heartburn and the simultaneously measured SR. Therefore, SR measurement has the potential of yielding clinically relevant information in the investigation of GERD.
对最近开发的酸暴露传感器进行的体外研究表明，该传感器对pH值低于4的酸的响应（SR）由酸度的持续时间和程度线性决定。目的是确定SR是否与酸诱导的食管黏膜损伤的严重程度以及酸诱导的烧心相关。
将pH值为1.5的盐酸或生理盐水注入猫的食管5 - 20分钟。同时，在注入端口下方进行传感器测量。由独立病理学家对组织学损伤进行评分。在15名正常受试者中，将pH值为1的盐酸注入食管，并每隔5分钟对烧心的严重程度（0 - 5分）进行评分。在10名在酸灌注期间出现烧心的受试者中，在烧心诱导时间减去5分钟时重复初始盐酸灌注，然后灌注经滴定至pH值为2的受试者自身胃液；再次每隔5分钟对烧心严重程度进行评分。在烧心评分为1、2和3分时，取出位于注入端口下方的酸暴露传感器。
发现猫食管黏膜损伤的SR与组织学评分之间具有良好的相关性（r = 0.64，P < 0.005）。烧心严重程度评分与酸暴露时间之间存在良好的关系（r = 0.84，P < 0.001），烧心严重程度与SR之间存在显著但较弱的关系。
在猫中，酸诱导的食管黏膜损伤的严重程度与SR之间存在良好的关系。在男性中，酸诱导的烧心严重程度与同时测量的SR之间存在显著相关性。因此，SR测量在胃食管反流病的研究中有可能产生临床相关信息。
