Gaudino Mario, Giordano Alessandro, Santarelli Pietro, Alessandrini Francesco, Nori Stefania Lucia, Trani Carlo, Gaudino Simona, Possati Gianfederico
Department of Cardiac Surgery, Catholic University, Rome, Italy.
J Nucl Cardiol. 2002 Nov-Dec;9(6):601-7. doi: 10.1067/mnc.2002.126681.
This study was conceived to explore the correspondence between scintigraphic imaging of the sympathetic innervation of human postischemic left ventricular aneurysms and direct immunohistochemical localization of the nerve fibers in the same area.
In 7 patients undergoing left ventricular aneurysmectomy for postischemic ventricular aneurysm, the findings of thallium 201 and metaiodobenzylguanidine myocardial scintigraphy were compared with direct immunohistochemical localization of the nerve fibers in the same area. This comparison showed good correspondence between scintigraphic and immunohistochemical data, although scintigraphy failed to detect areas of minimal sympathetic innervation. Moreover, microscopic analysis showed sympathetic nerve fibers with peculiar morphology and distribution in the aneurysmal zone.
There is a good correspondence between immunohistochemical and scintigraphic imaging in the detection of sympathetic cardiac nerves in human left ventricular aneurysms; a morphologically abnormal sympathetic reinnervation can be found in the aneurysmal area (although denervation can persist in some zones).
本研究旨在探讨人类缺血后左心室动脉瘤交感神经支配的闪烁显像与同一区域神经纤维的直接免疫组织化学定位之间的对应关系。
对7例因缺血后心室动脉瘤接受左心室动脉瘤切除术的患者，将铊201和间碘苄胍心肌闪烁显像的结果与同一区域神经纤维的直接免疫组织化学定位进行比较。尽管闪烁显像未能检测到交感神经支配最少的区域，但这种比较显示闪烁显像和免疫组织化学数据之间有良好的对应关系。此外，显微镜分析显示动脉瘤区域的交感神经纤维具有独特的形态和分布。
在检测人类左心室动脉瘤的交感心脏神经方面，免疫组织化学和闪烁显像之间有良好的对应关系；在动脉瘤区域可发现形态异常的交感神经再支配（尽管在某些区域去神经支配可能持续存在）。
