细菌CpG-DNA激活Toll样受体9（TLR9）。

Bacterial CpG-DNA licenses TLR9.

作者信息

Bauer S, Wagner H

机构信息

Institute for Medical Microbiology, Hygiene and Immunology, Trogerstrasse 9, 81675 Munich, Germany.

出版信息

Curr Top Microbiol Immunol. 2002;270:145-54. doi: 10.1007/978-3-642-59430-4_9.

DOI:10.1007/978-3-642-59430-4_9

PMID:12467249

Abstract

The family of Toll-like receptors (TLRs) plays an important role in the innate immune response to pathogens. TLRs sense pathogen associated molecular patterns (PAMP) and lead to the stimulation of immune cells. In man, so far ten members (TLR1-10) have been reported. This review focuses on TLR9 which is an essential component for the recognition of bacterial CpG-DNA. Expression of TLR9 and structural consideration as well as direct ligand interaction of TLR9 and CpG-DNA are discussed.

摘要

Toll样受体（TLR）家族在对病原体的天然免疫反应中发挥着重要作用。TLR可识别病原体相关分子模式（PAMP）并刺激免疫细胞。在人类中，迄今为止已报道了10个成员（TLR1 - 10）。本综述聚焦于TLR9，它是识别细菌CpG - DNA的关键组成部分。文中讨论了TLR9的表达、结构考量以及TLR9与CpG - DNA的直接配体相互作用。