Akazome Motohiro, Senda Kyoko, Ogura Katsuyuki
Department of Materials Technology, Faculty of Engineering, Chiba University, 1-33 Yayoicho, Inageku, Japan.
J Org Chem. 2002 Dec 13;67(25):8885-9. doi: 10.1021/jo0204451.
A simple dipeptide, (S)-phenylglycyl-(R)-phenylglycine (S,R-1), formed inclusion compounds with a small amide such as formamide, acetamide, N,N-dimethylformamide (DMF), or N,N-dimethylacetamide. By single-crystal X-ray analysis, the inclusion compounds were shown to have a wavy layer structure. The molecules of S,R-1 are arranged in parallel via ionic pairing of the carboxyl and amino groups to construct the wavy layers. The guest molecules were accommodated in a channel cavity between the layers by means of hydrogen bonding with (+)NH(3) of S,R-1. The cavity is surrounded by the phenyl groups of S,R-1 that conformationally rotate so as to make the cavity size fit the guest amide.
一种简单的二肽，（S）-苯基甘氨酰-（R）-苯基甘氨酸（S，R-1），与甲酰胺、乙酰胺、N，N-二甲基甲酰胺（DMF）或N，N-二甲基乙酰胺等小分子酰胺形成包合物。通过单晶X射线分析表明，这些包合物具有波浪层结构。S，R-1分子通过羧基和氨基的离子配对平行排列，构建波浪层。客体分子通过与S，R-1的（+）NH（3）形成氢键而容纳在层间的通道腔内。该腔被S，R-1的苯基围绕，苯基发生构象旋转以使腔的大小适合客体酰胺。
