Dennis John H
Department of Environmental Science, University of Bradford, West Yorkshire, UK.
Respir Care. 2002 Dec;47(12):1445-55; discussion 1455-8.
The delivery of nebulized drugs is poorly controlled and the choice of the most appropriate delivery device is poorly understood, particularly because of off-license prescriptions and a lack of evidence-based medicine. Standardized in vitro methods for measuring nebulizer performance have been adopted in Europe, by the 2001 publication of a European Standard, prEN13544-1. These standardized methods were subsequently incorporated within the European Respiratory Society nebulizer guidelines, which will provide clinicians with useful information to improve nebulizer therapies. Standards for measuring nebulizer performance should be considered in North America and elsewhere. Careful consideration should be given to either adopting the methods embodied in the European Standard or developing the basis for developing that standard further through the International Standards Organization. Either way, confusion among clinicians would be reduced and nebulizer safety and aerosol delivery efficiency increased by standardizing in vitro methods of nebulizer performance assessment.
雾化药物的输送控制不佳，对于最合适的输送装置的选择也了解不足，特别是由于无许可证处方以及缺乏循证医学。欧洲通过2001年发布的欧洲标准prEN13544-1采用了标准化的体外测量雾化器性能的方法。这些标准化方法随后被纳入欧洲呼吸学会的雾化器指南中，这将为临床医生提供有用信息以改善雾化治疗。北美和其他地区应考虑雾化器性能的测量标准。应仔细考虑采用欧洲标准中包含的方法，或通过国际标准化组织进一步发展该标准的基础。无论哪种方式，通过标准化雾化器性能评估的体外方法，临床医生之间的困惑将减少，雾化器安全性和气溶胶输送效率将提高。
