Dhand Rajiv
Division of Pulmonary, Critical Care, and Environmental Medicine, University of Missouri-Columbia, Columbia, MO 65212, USA.
Respir Care. 2002 Dec;47(12):1406-16; discussion 1416-8.
Several electronic nebulizer devices that use a vibrating mesh or plate with multiple apertures to generate a fine-particle, low-velocity aerosol have been marketed or will shortly become available for clinical use. These devices have a high efficiency of delivering aerosol to the lung, such that the nominal dose of drugs to be administered could be substantially reduced. Moreover, the volume of drug solution left in these new devices when the nebulization has ceased is negligible, so there is potential to improve the cost-effectiveness of administering expensive medications. Because these devices nebulize at a faster rate than conventional jet or ultrasonic nebulizers, the duration of each treatment could be shortened. These devices efficiently nebulize solutions and suspensions; they have been successfully used for aerosolizing insulin, other proteins and peptides, and fragments of DNA. They could be employed for a wide variety of clinical applications, including the delivery of aerosols for systemic therapy and gene transfer. These devices have overcome many of the limitations associated with conventional jet and ultrasonic nebulizers, and they offer the versatility to modify the aerosol characteristics according to the clinical application for which they are employed. With these devices clinicians will be able to precisely control drug delivery to the respiratory tract.
几种使用带有多个小孔的振动网或板来产生细颗粒、低速气雾剂的电子雾化器设备已上市销售，或很快将可供临床使用。这些设备将气雾剂输送到肺部的效率很高，以至于待给药的药物标称剂量可以大幅减少。此外，雾化停止时这些新设备中残留的药物溶液体积可忽略不计，因此有可能提高使用昂贵药物的成本效益。由于这些设备的雾化速度比传统的喷射式或超声雾化器快，每次治疗的时长可以缩短。这些设备能有效地雾化溶液和混悬液；它们已成功用于雾化胰岛素、其他蛋白质和肽以及DNA片段。它们可用于多种临床应用，包括用于全身治疗和气溶胶基因转移的气雾剂给药。这些设备克服了许多与传统喷射式和超声雾化器相关的局限性，并且它们具有根据所用于的临床应用来改变气雾剂特性的通用性。有了这些设备，临床医生将能够精确控制药物向呼吸道的输送。
