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[体外心室辅助装置在扩张型心肌病患者中的循环支持作用]

[External ventricular assist devices as circulatory support in patients with dilated cardiomyopathy].

作者信息

Granados Molina A, García Menor E, Jaraba Caballero S, Ibarra de la Rosa I, Ulloa Santamaría E, Pérez Navero J L, Arizón de Prado J M feminine, Merino Cejas C

机构信息

Unidad de Cuidados Intensivos Pediátricos. Hospital Universitario Reina Sofía. Córdoba. España.

出版信息

An Esp Pediatr. 2002 Nov;57(5):480-3.

Abstract

Ventricular assist devices have demonstrated their utility in patients with intractable cardiac failure, both as support until complete myocardial recovery and as a bridge to transplantation. Specific pediatric pneumatic paracorporeal systems can be applied even in infants. Long-term survival has been reported although experience is limited. We report the case of an 8-year-old boy with dilated cardiomyopathy awaiting cardiac transplantation. The patient developed profound cardiogenic shock with multiorgan failure while being evaluated for heart transplantation. He was given biventricular assistance with the MEDOS-HIA system (MEDOS-Helmholtz Institute). Maximum stroke volume ventricles of 25 and 22 ml were used, achieving a cardiac output of 2.2 l/min in both ventricles. The patient was supported with ventricular assistance for 9 days, but multiple organ failed to improve and transplantation became impossible. Progressive loss of peripheral circulatory resistance unresponsive to treatment developed and ventricular assistance was discontinued. The previous severe shock and advanced and progressive multiorgan failure could be responsible for the poor outcome of our patient despite maintenance of adequate cardiac output. Nevertheless, the use of ventricular assist devices is a real therapeutic alternative in children with severe cardiogenic shock, allowing them to recover completely or undergo heart transplantation. Patient selection, the choice of a system of appropriate size, and early implantation seem to be the cornerstones for obtaining good results.

摘要

心室辅助装置已在顽固性心力衰竭患者中显示出其效用,既作为支持手段直至心肌完全恢复,也作为移植的桥梁。特定的儿科气动体外系统甚至可应用于婴儿。尽管经验有限,但已有长期存活的报道。我们报告一例8岁扩张型心肌病男孩等待心脏移植的病例。该患者在接受心脏移植评估时出现严重的心源性休克伴多器官衰竭。他接受了MEDOS-HIA系统(MEDOS-亥姆霍兹研究所)的双心室辅助。使用的心室最大搏出量分别为25毫升和22毫升,两个心室的心输出量均达到2.2升/分钟。患者接受心室辅助支持9天,但多器官功能未能改善,移植已不可能。出现对治疗无反应的外周循环阻力进行性丧失,遂停止心室辅助。尽管维持了足够的心输出量,但先前的严重休克以及晚期和进行性多器官衰竭可能是导致我们患者预后不良的原因。然而,对于严重心源性休克的儿童,使用心室辅助装置是一种切实可行的治疗选择,可使他们完全康复或接受心脏移植。患者选择、合适尺寸系统的选择以及早期植入似乎是取得良好效果的基石。

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