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库尔特·维特里希与生物大分子的核磁共振

Kurt Wüthrich and NMR of biological macromolecules.

作者信息

Palmer Arthur G, Patel Dinshaw J

机构信息

Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10025, USA.

出版信息

Structure. 2002 Dec;10(12):1603-4. doi: 10.1016/s0969-2126(02)00915-2.

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is the only experimental technique that can determine the structures and dynamics of biological macromolecules and their complexes in solution and with atomic resolution. The award of the 2002 Nobel Prize in Chemistry to Kurt Wüthrich of the Swiss Federal Institute of Technology and The Scripps Research Institute honors his pioneering efforts in developing and applying this technique. Wüthrich shared the prize with John B. Fenn and Koichi Tanaka, who were recognized for the development of ionization methods for the analysis of proteins using mass spectrometry.

摘要

核磁共振(NMR)光谱学是唯一一种能够在溶液中以原子分辨率测定生物大分子及其复合物的结构和动力学的实验技术。瑞士联邦理工学院和斯克里普斯研究所的库尔特·维特里希荣获2002年诺贝尔化学奖,以表彰他在开发和应用这项技术方面的开拓性努力。维特里希与约翰·B·芬恩和田中耕一共同获得该奖项,他们因开发用于蛋白质分析的质谱电离方法而受到认可。

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