Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells.
作者信息
Kakuta Hiroki, Koiso Yukiko, Nagasawa Kazuo, Hashimoto Yuichi
机构信息
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Japan.
出版信息
Bioorg Med Chem Lett. 2003 Jan 6;13(1):83-6. doi: 10.1016/s0960-894x(02)00845-4.
Abstract
Non-peptide, small-molecular, non-competitive inhibitors of puromycin-sensitive aminopeptidase (PSA), that is, 3-(2,6-diethylphenyl)-2,4(1H,3H)-quinazolinedione (PAQ-22, 3) and its 1N-methyl analogue (MPAQ-22 4), were structurally modified to afford fluorescent bioprobes, ANTAQ (5) and DAMPAQ-22 (6). The cellular localization of PSA could be visualized by the use of these fluorescent bioprobes.
摘要
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