Ablin R J
Urology. 1976 Jan;7(1):39-47. doi: 10.1016/0090-4295(76)90559-8.
The relationship between the level of the three major serum immunoglobulins, IgG, IgA, and IgM and of the third component of complement (C')C'3(B1A-globulin) and the clinical Stage of prostatic cancer was evaluated. While, statistically significant (P less than 0.05) differences in the levels of these proteins compared with their levels in patients with benign prostatic hypertrophy (applied only to the study of C'3) and healthy adults were observed, the levels of these proteins in each of the Stages evaluated were not significantly different from each other. The absence of a correlation between the Stage of disease and the levels of these humorally mediated effectors of immunologic responsiveness is in keeping with observations of cell-mediated effectors of immunologic responsiveness in prostatic cancer patients. Observation of the association of prostatic cancer with a deficiency of B-cell function and of C'3 is noted.
评估了血清中三种主要免疫球蛋白IgG、IgA和IgM以及补体第三成分（C'）C'3（β1A球蛋白）的水平与前列腺癌临床分期之间的关系。虽然与良性前列腺增生患者（仅用于C'3的研究）和健康成年人相比，这些蛋白质水平存在统计学上的显著差异（P小于0.05），但在评估的每个分期中，这些蛋白质的水平彼此之间没有显著差异。疾病分期与这些免疫反应的体液介导效应物水平之间缺乏相关性，这与前列腺癌患者免疫反应的细胞介导效应物的观察结果一致。值得注意的是，观察到前列腺癌与B细胞功能缺陷和C'3缺乏有关。
