Huang Lily, Brinen Linda S, Ellman Jonathan A
Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley 94720, USA.
Bioorg Med Chem. 2003 Jan 2;11(1):21-9. doi: 10.1016/s0968-0896(02)00427-3.
The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.
已分别在1.1埃和1.2埃的分辨率下测定了与半胱氨酸蛋白酶克鲁兹蛋白酶复合的两种羟甲基酮抑制剂的晶体结构。这些高分辨率晶体结构提供了与克鲁兹蛋白酶结合的非共价抑制剂的首个结构。基于这些结构制备并测试了一系列化合物，从而进一步深入了解关键的结合相互作用。
