bcl家族表达在反复缺血诱导的空间记忆损伤中的作用。

Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia.

作者信息

Irie Keiichi, Mishima Kenichi, Ishibashi Daisuke, Egashira Nobuaki, Iwasaki Katsunori, Fujiwara Michihiro

机构信息

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 814-0180, Fukuoka, Japan.

出版信息

Life Sci. 2002 Dec 20;72(4-5):621-9. doi: 10.1016/s0024-3205(02)02270-1.

DOI:10.1016/s0024-3205(02)02270-1

PMID:12467903

Abstract

In the present study, we examined the effects of repeated ischemia (10 min x 2, 1 hr interval) on spatial memory in rats in an 8-arm radial maze test compared with single ischemia (10 min x 1). Repeated ischemia produced more severe impairment of spatial memory and stronger TUNEL-positive immunoreactivity in the hippocampal CA1 region than single ischemia at 7 days after reperfusion. Moreover, repeated ischemia altered bcl-family expression, which is related to apoptosis, while this was not affected by single ischemia. These results suggest that spatial memory impairment at 7 days after repeated ischemia may be related to apoptosis in hippocampal CA1 cells.

摘要

在本研究中，我们在八臂放射状迷宫试验中检测了重复缺血（10分钟×2次，间隔1小时）与单次缺血（10分钟×1次）相比对大鼠空间记忆的影响。与再灌注后7天的单次缺血相比，重复缺血导致更严重的空间记忆损害以及海马CA1区更强的TUNEL阳性免疫反应性。此外，重复缺血改变了与细胞凋亡相关的bcl家族表达，而单次缺血对此没有影响。这些结果表明，重复缺血后7天的空间记忆损害可能与海马CA1区细胞的凋亡有关。