Tsuchiya Shigeru
Department of Pediatric Oncology, Research Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Crit Rev Oncol Hematol. 2002 Dec;44(3):227-38. doi: 10.1016/s1040-8428(02)00114-2.
Epstein-Barr virus (EBV) is a common DNA virus distributed worldwide. Usually the initial infection involves the upper respiratory tract without any problems and almost the entire population more than 25 years old test positive for anti-EBV antibodies. However, EBV often causes not only acute lytic infection but also chronic active infection with B cells and even T cells. In addition the EBV genome has been detected in tumors of hematopoietic or epithelial cell origin such as Burkitt's lymphomas, Hodgkin's disease, NK/T cell lymphomas, nasopharyngeal carcinomas (NPCs) and gastric adenocarcinomas. It is clearly important to make a correct diagnosis for EBV associated diseases and monitor the EBV load in individual patients for an appropriate therapy. In this paper recent advances in serological, immunological and molecular approaches for detection of EBV associated disease are described.
爱泼斯坦-巴尔病毒（EBV）是一种常见的DNA病毒，广泛分布于全球。通常，初次感染累及上呼吸道时不会出现任何问题，几乎所有25岁以上的人群抗EBV抗体检测呈阳性。然而，EBV不仅常引起急性裂解感染，还会导致B细胞甚至T细胞的慢性活动性感染。此外，在造血或上皮细胞来源的肿瘤中已检测到EBV基因组，如伯基特淋巴瘤、霍奇金病、NK/T细胞淋巴瘤、鼻咽癌（NPC）和胃腺癌。对EBV相关疾病做出正确诊断并监测个体患者的EBV载量以进行适当治疗显然很重要。本文描述了检测EBV相关疾病的血清学、免疫学和分子方法的最新进展。
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