Myers Ralph, Hume Susan
Imaging Research Solutions Limited, Cyclotron Building, Hammersmith Hospital, Ducane Road, W12 0NN, London, UK.
Eur Neuropsychopharmacol. 2002 Dec;12(6):545-55. doi: 10.1016/s0924-977x(02)00103-7.
Positron emission tomography (PET) has well-established strengths which are commonly exploited in human clinical research. Not least of these are its dynamic and quantitative capabilities. The recent growth in small animal PET, spurred on by technological developments and an interest in the application of imaging to the field of genomics in mice, has seen impressive improvements in image spatial resolution. The availability of commercial small animal PET scanners has meant a broadening of the user base away from PET development environments and into experimental laboratories. This paper will review these developments and assess the impact on overall data quality.
正电子发射断层扫描（PET）具有公认的优势，这些优势在人类临床研究中经常得到利用。其中尤其重要的是其动态和定量能力。随着技术的发展以及对成像技术在小鼠基因组学领域应用的兴趣，小动物PET近年来发展迅速，图像空间分辨率有了显著提高。商用小动物PET扫描仪的出现意味着用户群体从PET研发环境扩大到了实验实验室。本文将回顾这些发展情况，并评估其对整体数据质量的影响。
