（111）铟-二乙三胺五乙酸（0）-奥曲肽对部分肝切除术后肝内肿瘤生长的抑制作用。

The inhibitory effect of (111)In-DTPA(0)-octreotide on intrahepatic tumor growth after partial hepatectomy.

作者信息

Slooter Gerrit D, Aalbers Arend G J, Breeman Wouter A P, Hiemstra Coen A, Marquet Richard L, Krenning Eric P, van Eijck Casper H J

机构信息

Department of Surgery, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.

出版信息

J Nucl Med. 2002 Dec;43(12):1681-7.

PMID:12468520

Abstract

UNLABELLED

The aim of this animal study was to evaluate whether peptide receptor radionuclide therapy with (111)In-diethylenetriaminepentaacetic acid (DTPA)(0)-octreotide was able to reduce tumor growth even under tumor growth-stimulating conditions induced by partial hepatectomy (PHx).

METHODS

Rats underwent 70% PHx or sham operation. The development of hepatic metastases was determined 21 d after direct injection of somatostatin receptor (SS-R)-positive or SS-R-negative tumor cells into the portal vein. Groups of 8 or 9 animals that underwent PHx or sham operation were treated with octreotide 50 micro g/kg subcutaneously twice daily or with 370 MBq (111)In-DTPA(0)-octreotide intravenously on days 1 and 8. Both treatments were compared with control treatment. Forty non-tumor-bearing rats were used to determine the influence of (111)In-DTPA(0)-octreotide therapy on liver regeneration after PHx.

RESULTS

PHx induced an increase in tumor growth in all experiments (P < 0.01). Octreotide treatment did not influence tumor growth after PHx or sham operation. (111)In-DTPA(0)-octreotide could effectively reduce tumor growth in the liver of SS-R-positive tumors also under conditions of increased tumor growth as generated by PHx (P < 0.01). (111)In-DTPA(0)-octreotide was also effective on SS-R-negative tumors after PHx (P = 0.01) but not after sham operation. Furthermore, (111)In-DTPA(0)-octreotide therapy did not influence liver regeneration or liver function after PHx.

CONCLUSION

Peptide receptor radionuclide therapy with (111)In-DTPA(0)-octreotide is effective in SS-R-positive tumors. During liver regeneration, the growth of SS-R-negative tumors is also reduced. This effect is not induced by impairment of liver regeneration or liver function. Radionuclide therapy could therefore be a promising treatment modality for patients with symptomatic liver metastases of neuroendocrine tumors in combination with liver resection.

摘要

未标记

本动物研究的目的是评估用（111）铟 - 二乙三胺五乙酸（DTPA）（0） - 奥曲肽进行肽受体放射性核素治疗是否能够在部分肝切除术（PHx）诱导的肿瘤生长刺激条件下仍能减少肿瘤生长。

方法

大鼠接受70%肝部分切除术或假手术。在将生长抑素受体（SS - R）阳性或SS - R阴性肿瘤细胞直接注入门静脉21天后，确定肝转移的发生情况。接受肝部分切除术或假手术的8或9只动物组，在第1天和第8天每天两次皮下注射50μg/kg奥曲肽或静脉注射370MBq（111）铟 - DTPA（0） - 奥曲肽。将这两种治疗方法与对照治疗进行比较。使用40只未荷瘤大鼠来确定（111）铟 - DTPA（0） - 奥曲肽治疗对肝部分切除术后肝脏再生的影响。

结果

在所有实验中，肝部分切除术均诱导肿瘤生长增加（P < 0.01）。奥曲肽治疗对肝部分切除术或假手术后的肿瘤生长没有影响。（111）铟 - DTPA（0） - 奥曲肽在肝部分切除术所产生的肿瘤生长增加的情况下，也能有效减少SS - R阳性肿瘤在肝脏中的生长（P < 0.01）。（111）铟 - DTPA（0） - 奥曲肽对肝部分切除术后的SS - R阴性肿瘤也有效（P = 0.01），但对假手术后的肿瘤无效。此外，（111）铟 - DTPA（0） - 奥曲肽治疗对肝部分切除术后的肝脏再生或肝功能没有影响。