Sakai Katsuyuki, Passingham Richard E
Wellcome Department of Cognitive Neurology, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK.
Nat Neurosci. 2003 Jan;6(1):75-81. doi: 10.1038/nn987.
When task instructions are given, the human brain establishes a task set before the task is actually performed. By introducing a delay between the instruction and the task, we have identified the neural correlates of task sets using functional magnetic resonance imaging (fMRI). Subjects were instructed to remember a sequence of positions or letters, either in the order presented or in the reverse order. Spatial or verbal processing areas were active during the delay, depending on whether positions or letters were to be remembered, whereas the anterior region of the prefrontal cortex (PFC) was active regardless of the domain of the items. Furthermore, the nature of the interaction between the anterior PFC and the domain-specific posterior prefrontal areas (superior frontal sulcus and left inferior frontal gyrus) depended on whether the items were to be remembered in the forward or backward order. Thus we have identified inter-regional interactions that reflect preparation for task performance.
当给出任务指令时，人类大脑会在实际执行任务之前建立一个任务集。通过在指令和任务之间引入延迟，我们利用功能磁共振成像（fMRI）确定了任务集的神经关联。受试者被要求按呈现顺序或相反顺序记住一系列位置或字母。在延迟期间，空间或语言处理区域会活跃，这取决于要记住的是位置还是字母，而前额叶皮层（PFC）的前部区域无论项目的领域如何都会活跃。此外，前额叶皮层前部与特定领域的前额叶后部区域（额上沟和左额下回）之间相互作用的性质取决于项目是按正向还是反向顺序被记住。因此，我们确定了反映任务执行准备情况的区域间相互作用。
