White J D, MacPherson I R J, Evans T R J
Cancer Research UK Department of Medical Oncology, Beatson Oncology Centre, Western Infirmary, Glasgow, G11 6NT, UK.
Oncol Rep. 2003 Jan-Feb;10(1):249-51.
Neutropenia is frequently observed in the practice of oncology, usually resulting from the use of cytotoxic drugs. Less frequently, neutropenia is due to infiltration of the bone marrow by malignant disease. Both of these usually cause some depletion of all haematopoietic linages. True isolated neutropenia is, in contrast, a less frequent phenomenon. We report a case of auto-immune neutropenia occurring in a patient with metastatic melanoma, and discuss the differential diagnosis and implications for patient management.
中性粒细胞减少症在肿瘤学实践中经常可见，通常是由细胞毒性药物的使用所致。较少见的情况是，中性粒细胞减少症是由于恶性疾病浸润骨髓引起的。这两种情况通常都会导致所有造血谱系出现一定程度的减少。相比之下，真正的孤立性中性粒细胞减少症是一种较罕见的现象。我们报告了一例转移性黑色素瘤患者发生自身免疫性中性粒细胞减少症的病例，并讨论了鉴别诊断以及对患者管理的影响。
