Tosi M R, Bottura G, Lucchi P, Reggiani A, Trinchero A, Tugnoli V
Istituto di Citomorfologia Normale e Patologica del CNR, Bologna, Italy.
Int J Mol Med. 2003 Jan;11(1):95-8. doi: 10.3892/ijmm.11.1.95.
Cholesteryl esters (CholE) were detected in human malignant neoplasms by means of in vitro nuclear magnetic resonance spectroscopy. Spectroscopic analysis of the total lipid extracts obtained from cerebral tumors revealed appreciable amount of esterified cholesterol in high grade gliomas such as glioblastomas and anaplastic oligodendrogliomas, characterized by prominent neovascularity. The finding that no CholE were detected in the healthy brain and in low grade and benign tumors supports a possible correlation between this class of lipids and histological vascular proliferation. Compared with high grade gliomas, renal cell carcinomas show higher levels of CholE, absent in the healthy renal parenchyma and in benign oncocytomas. In nefro-carcinomas, cytoplasmic lipid inclusions and prominent vascularization contribute to the increased levels of CholE present mainly as oleate. CholE are discussed as potential biochemical markers of cancer and as a target for new therapeutic strategies.
通过体外核磁共振波谱法在人类恶性肿瘤中检测到了胆固醇酯（CholE）。对从脑肿瘤中获得的总脂质提取物进行的光谱分析显示，在高级别胶质瘤如胶质母细胞瘤和间变性少突胶质细胞瘤中存在可观量的酯化胆固醇，这些肿瘤的特征是具有显著的新生血管。在健康大脑以及低级别和良性肿瘤中未检测到CholE这一发现支持了这类脂质与组织学血管增殖之间可能存在的相关性。与高级别胶质瘤相比，肾细胞癌中CholE水平更高，而在健康肾实质和良性嗜酸性细胞瘤中则不存在。在肾癌中，细胞质脂质包涵体和显著的血管生成导致了主要以油酸酯形式存在的CholE水平升高。胆固醇酯被作为癌症的潜在生化标志物以及新治疗策略的靶点进行了讨论。
