Mennemeyer R P, Kjeldsberg C R
Am J Clin Pathol. 1976 Jan;65(1):45-8. doi: 10.1093/ajcp/65.1.45.
Lymphoid hyperplasia of the bone marrow occasionally resembles malignant lymphoma and may lead to confusion in bone marrow interpretation. The case of a patient with an unusual variant of isolated bone marrow lymphoid hyperplasia in which histologic overlap with lymphoma was found is presented. The case illustrates the difficulties in bone marrow interpretation that lymphoid hyperplasia can present. One cannot always rely on the number, size, or general pattern of lymphoid nodules to determine whether a lesion is benign or malignant. We suggest that when isolated lymphoid hyperplasia is composed of mature lymphocytes and confined to the marrow, a diagnosis of malignant lymphoproliferative disease should not be made.
骨髓的淋巴样增生偶尔会类似于恶性淋巴瘤，可能会导致骨髓判读出现混淆。本文介绍了一例患有孤立性骨髓淋巴样增生异常变体的患者，该病例中发现了与淋巴瘤的组织学重叠。该病例说明了淋巴样增生可能给骨髓判读带来的困难。不能总是依靠淋巴小结的数量、大小或总体模式来确定病变是良性还是恶性。我们建议，当孤立性淋巴样增生由成熟淋巴细胞组成且局限于骨髓时，不应做出恶性淋巴增殖性疾病的诊断。
