营养不足对大鼠脑内GMP-PNP结合及腺苷酸环化酶活性的影响。
Effect of undernutrition on GMP-PNP binding and adenylate cyclase activity from rat brain.
作者信息
Rotta Liane N, Nogueira Cristina W, da Silva Luciane, Soares Félix A, Perry Marcos L S, Souza Diogo O
机构信息
Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
出版信息
Cell Mol Neurobiol. 2002 Jun;22(3):365-72. doi: 10.1023/a:1020780220520.
Abstract
- Undernutrition is an insult that affects brain development and functioning. Considering that signaling through metabotropic receptors/G proteins is critical for normal synaptic transmission and contributes to CNS development and synaptic plasticity, the present study investigated the effects of pre- and postnatal protein deprivation (diet: 8% protein; normonourished group: 25% protein) on brain signal transduction by G proteins. 2. Undernutrition decreased the [3H] GMP-PNP binding to G proteins and AC activity, in neural plasma synaptic membranes of 21- and 75-day-old rats. This effect was less pronounced or even absent in old rats. 3. Ontogenetically, the dietary treatment effect might be interpreted as a retarded development associated with protein malnutrition.
摘要
- 营养不足是一种影响大脑发育和功能的损害因素。鉴于通过代谢型受体/G蛋白进行的信号传导对于正常突触传递至关重要，并有助于中枢神经系统发育和突触可塑性，本研究调查了产前和产后蛋白质剥夺（饮食：8%蛋白质；正常营养组：25%蛋白质）对G蛋白介导的脑信号转导的影响。2. 营养不足降低了21日龄和75日龄大鼠神经血浆突触膜中[3H]鸟苷-5′-三磷酸（GMP-PNP）与G蛋白的结合以及腺苷酸环化酶（AC）活性。在老年大鼠中，这种作用不太明显甚至不存在。3. 从个体发生角度来看，饮食处理的影响可能被解释为与蛋白质营养不良相关的发育迟缓。
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