Olin J W
Vascular Medicine Programme, Mount Sinai School of Medicine, The Zena and Michael A Wiener Cardiovascular Institute, New York, NY 10029-6574, USA.
Int J Clin Pract. 2002 Nov;56(9):687-93.
Intermittent claudication, the most common symptomatology of peripheral arterial disease, is characterised by lower-extremity discomfort induced by exercise and relieved by rest. The most serious potential outcome of the condition is increased morbidity and mortality from cardiovascular disease, with which it is often associated, thus prompt diagnosis and management are crucial. Therapy consists of structured exercise and reduction of cardiovascular risk factors, followed by or together with pharmacological interventions with anticlaudicants (cilostazol or pentoxifylline) and specific antiplatelet agents (aspirin, clopidogrel). Revascularisation procedures are indicated in those with limb-threatening or lifestyle disabling disease.
间歇性跛行是外周动脉疾病最常见的症状，其特征是运动诱发下肢不适，休息后缓解。该疾病最严重的潜在后果是常与之相关的心血管疾病导致的发病率和死亡率增加，因此及时诊断和治疗至关重要。治疗包括有规律的运动和降低心血管危险因素，随后或同时进行使用抗跛行药物（西洛他唑或己酮可可碱）和特定抗血小板药物（阿司匹林、氯吡格雷）的药物干预。对于有肢体威胁或致残性疾病的患者，需进行血运重建手术。
