Agrawal Kush, Eberhardt Robert T
Cardiovascular and Endovascular Intervention, Section of Cardiovascular Medicine, Boston Medical Center, Boston, MA 02118, USA.
Vascular Medicine Program, Section of Cardiovascular Medicine, Boston Medical Center, Boston University School of Medicine, 88 East Newton Street, Boston MA 02118, USA.
Cardiol Clin. 2015 Feb;33(1):111-37. doi: 10.1016/j.ccl.2014.09.010.
Peripheral arterial disease (PAD) is primarily caused by progressive systemic atherosclerosis manifesting in the lower extremities. This review addresses the epidemiology, clinical presentation and evaluation, and medical management of PAD, with a focus on intermittent claudication. Key advances in the recognition of cardiovascular risk in asymptomatic individuals with mildly abnormal ankle-brachial index, newer reflections on exercise therapy, and a review of established and investigational agents for the treatment of symptomatic PAD, such as cilostazol, statins, and angiotensin-converting enzyme inhibitors, are highlighted.
外周动脉疾病（PAD）主要由进展性全身动脉粥样硬化引起，表现于下肢。本综述阐述了PAD的流行病学、临床表现与评估以及药物治疗，重点关注间歇性跛行。文中强调了在踝臂指数轻度异常的无症状个体中识别心血管风险方面的关键进展、对运动疗法的新思考，以及对已确立的和正在研究的用于治疗有症状PAD的药物（如西洛他唑、他汀类药物和血管紧张素转换酶抑制剂）的综述。
