用于医药有机合成中作为催化剂或连接体的聚合物负载金属膦配合物。

Polymer-supported metal-phosphine complexes for use as catalysts or linkers in medicinally-oriented organic synthesis.

作者信息

Leadbeater Nicholas E

机构信息

Department of Chemistry, King's College London, Strand, London, WC2R 2LS, UK.

出版信息

Curr Med Chem. 2002 Dec;9(23):2147-71. doi: 10.2174/0929867023368700.

DOI:10.2174/0929867023368700

PMID:12470252

Abstract

Polymer-supported catalysts and reagents have found many uses in synthetic organic chemistry. This review discusses the preparation of polymer-supported phosphine ligands and organometallic complexes formed using these and highlights their use in reactions that are of particular interest to medicinal chemists. The scope of the review is limited to phosphine ligands and their metal complexes attached to derivitised polystyrene supports.

摘要

聚合物负载的催化剂和试剂在有机合成化学中已有诸多应用。本综述讨论了聚合物负载膦配体的制备以及使用这些配体制备的有机金属配合物，并着重介绍了它们在药物化学家特别感兴趣的反应中的应用。本综述的范围仅限于连接到衍生化聚苯乙烯载体上的膦配体及其金属配合物。