Gordon Keith
Reproductive Medicine, Organon Pharmaceuticals Inc, 56 Livingston Avenue - 4th Floor, Roseland, NJ 07068, USA.
Reprod Biomed Online. 2002 Nov-Dec;5(3):259-64. doi: 10.1016/s1472-6483(10)61829-9.
This article reviews the past, present, and future of gonadotrophin therapy, including purification of gonadotrophins from animal or human urine sources and production of gonadotrophins through recombinant technology. With the advent of recombinant DNA methodologies combined with site-directed mutagenesis, a variety of structural modifications becomes possible.
本文回顾了促性腺激素治疗的过去、现在和未来,包括从动物或人尿源中纯化促性腺激素以及通过重组技术生产促性腺激素。随着重组DNA方法与定点诱变技术的出现,多种结构修饰成为可能。