Ansari Aseem Z, Mapp Anna K
Department of Biochemistry and The Genome Center, 433 Babcock Drive, University of Wisconsin-Madison, Madison, WI 53706, USA.
Curr Opin Chem Biol. 2002 Dec;6(6):765-72. doi: 10.1016/s1367-5931(02)00377-0.
Eukaryotic transcription factors are composed of interchangeable modules. This has led to the design of a wide variety of modular artificial transcription factors (ATFs) that can stimulate or inhibit the expression of targeted genes. The ability to regulate the expression of any targeted gene using a 'programmable' ATF offers a powerful tool for functional genomics and bears tremendous promise in developing the field of transcription-based therapeutics.
真核转录因子由可互换的模块组成。这导致了各种各样模块化人工转录因子（ATF）的设计，这些因子能够刺激或抑制目标基因的表达。使用“可编程”的ATF调控任何目标基因表达的能力为功能基因组学提供了一个强大的工具，并在基于转录的治疗领域发展中具有巨大的前景。
