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血液透析患者氧化应激、肝细胞生长因子与肝脏疾病之间的关系。

Relations between oxidative stress, hepatocyte growth factor, and liver disease in hemodialysis patients.

作者信息

Borawski Jacek, Pawlak Krystyna, Naumnik Beata, Myśliwiec Michal

机构信息

Department of Nephrology and Internal Medicine, Medical Academy, Białystok, Poland.

出版信息

Ren Fail. 2002 Nov;24(6):825-37. doi: 10.1081/jdi-120015684.

Abstract

BACKGROUND

Hepatocyte growth factor (HGF) and copper/zinc superoxide dismutase (Cu/Zn SOD) protect against tissue injury, including that due to oxidative stress (SOX). We studied whether they could be associated with each other, SOX markers, prevalence of viral hepatitis, and cardiovascular disease (CVD) and their laboratory surrogates in maintenance hemodialysis (HD) patients.

METHODS

In 24 patients, pre-dialysis serum HGF, plasma Cu/Zn SOD, total lipid peroxides, and serum autoantibodies against oxidized LDL were measured by ELISAs. Viral hepatitis B and C markers were determined by third generation microparticle ELISAs, and CVD was identified on a clinical basis.

RESULTS

In HD patients, circulating HGF, Cu/Zn SOD, and the other SOX markers were higher than in healthy controls, and HGF directly correlated with Cu/Zn SOD levels (P = 0.0006). Both HGF (P = 0.021) and Cu/Zn SOD (P=0.017) were positively associated with prevalence of viral hepatitis and serum alanine aminotransferase activity (P = 0.021 and P=0.040, respectively). Presence of CVD directly correlated with HGF (P = 0.001) but not with Cu/Zn SOD levels (P = 0.087). Circulating HGF positively related to serum C-reactive protein (P = 0.043). In patients without viral hepatitis and CVD, both HGF and Cu/Zn SOD were lower than in those with, and higher than in healthy controls. CVD (P = 0.003) and viral hepatitis (P = 0.024) were independent predictors of increased HGF, while positive viral hepatitis marker predicted increased Cu/Zn SOD levels (P = 0.019) in HD patients. There were no associations between HGF and the SOX markers in controls.

CONCLUSIONS

In maintenance HD patients, circulating Cu/Zn SOD and HGF levels are increased, likely as a part of the reparatory reaction against liver damage. Viral hepatitis status and liver function should be considered in further studies of Cu/Zn SOD in these subjects.

摘要

背景

肝细胞生长因子(HGF)和铜/锌超氧化物歧化酶(Cu/Zn SOD)可预防组织损伤,包括氧化应激(SOX)所致的损伤。我们研究了它们是否与维持性血液透析(HD)患者的SOX标志物、病毒性肝炎患病率、心血管疾病(CVD)及其实验室替代指标相关。

方法

对24例患者进行透析前血清HGF、血浆Cu/Zn SOD、总脂质过氧化物以及抗氧化型低密度脂蛋白血清自身抗体的酶联免疫吸附测定(ELISA)。采用第三代微粒ELISA法检测乙型和丙型病毒性肝炎标志物,并根据临床情况确定CVD。

结果

HD患者的循环HGF、Cu/Zn SOD及其他SOX标志物高于健康对照,且HGF与Cu/Zn SOD水平直接相关(P = 0.0006)。HGF(P = 0.021)和Cu/Zn SOD(P = 0.017)均与病毒性肝炎患病率和血清丙氨酸转氨酶活性呈正相关(分别为P = 0.021和P = 0.040)。CVD的存在与HGF直接相关(P = 0.001),但与Cu/Zn SOD水平无关(P = 0.087)。循环HGF与血清C反应蛋白呈正相关(P = 0.043)。在无病毒性肝炎和CVD的患者中,HGF和Cu/Zn SOD均低于有病毒性肝炎和CVD的患者,但高于健康对照。CVD(P = 0.003)和病毒性肝炎(P = 0.024)是HD患者HGF升高的独立预测因素,而病毒性肝炎阳性标志物预测HD患者Cu/Zn SOD水平升高(P = 0.019)。在对照中,HGF与SOX标志物之间无关联。

结论

在维持性HD患者中,循环Cu/Zn SOD和HGF水平升高,可能是针对肝脏损伤的修复反应的一部分。在对这些患者的Cu/Zn SOD进行进一步研究时,应考虑病毒性肝炎状态和肝功能。

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