抑郁症患者血清肝细胞生长因子（HGF）水平降低与疾病严重程度相关。
Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Depression Correlates with Severity of Disease.
作者信息
Russo A J
机构信息
Research Director, Health Research Institute/Pfeiffer Treatment Center, Warrenville, Illinois 60555, USA.
出版信息
Biomark Insights. 2010 Aug 3;5:63-7. doi: 10.4137/bmi.s5183.
AIM
To assess serum Hepatocyte Growth Factor (HGF) levels in individuals with depression and to test the hypothesis that there is a relationship between severity of depression and HGF concentration.
SUBJECTS AND METHODS
Serum from 26 clinically depressed individuals and 19 controls were tested for serum HGF using ELISAs. Correlation was established between HGF concentration and disease severity.
RESULTS
Depressed individuals had significantly lower serum levels of HGF compared to controls (P < 0.0001). HGF concentration correlated with overall depressive behavior (P = 0.03) and specifically depression (P = 0.02), but not anxiety (P = 0.36).
DISCUSSION
These results suggest an association between HGF serum levels and clinically depressed individuals and demonstrate a correlation between severity of depression and HGF levels. Further studies of the predictive strength of HGF as a biomarker for depression may be warranted.
目的
评估抑郁症患者的血清肝细胞生长因子（HGF）水平，并检验抑郁症严重程度与HGF浓度之间存在关联这一假设。
对象与方法
采用酶联免疫吸附测定法（ELISA）检测26例临床抑郁症患者和19例对照者的血清HGF。建立HGF浓度与疾病严重程度之间的相关性。
结果
与对照组相比，抑郁症患者的血清HGF水平显著降低（P < 0.0001）。HGF浓度与总体抑郁行为相关（P = 0.03），与特定的抑郁症状相关（P = 0.02），但与焦虑无关（P = 0.36）。
讨论
这些结果表明HGF血清水平与临床抑郁症患者之间存在关联，并证明抑郁症严重程度与HGF水平之间存在相关性。可能有必要进一步研究HGF作为抑郁症生物标志物的预测强度。
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