Shidham Vinod B, Asma Zeenat, Rao R Nagarjun, Chavan Ashwini, Machhi Jinobya, Almagro Urias, Komorowski Richard A
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA.
Am J Clin Pathol. 2002 Dec;118(6):895-902. doi: 10.1309/N46X-JW4D-DYXF-DB4Y.
The identification of parathyroid gland tissue and its distinction from adjacent structures such as thyroid gland, lymphoid, fibroadipose, and, rarely, thymic tissues on frozen section (FS) may be challenging owing to freezing artifact. Intraoperative cytology (IC) provides valuable complementary morphologic details. We evaluated 72 specimens with IC alone (group 1), followed by interpretation with FS to reach a final interpretation using IC and FS together (group 2). An additional 105 specimens were evaluated by FS alone (group 3). Permanent section diagnosis was used as the "gold standard." Sensitivity and specificity were 100% for group 2, compared with lower values for group 1 (98% and 100%, respectively) and group 3 (94% and 94%, respectively). IC is a valuable adjunct to FS during intraoperative consultation for evaluation of tissue in a parathyroid location.
由于冷冻假象，在冰冻切片（FS）上识别甲状旁腺组织并将其与相邻结构（如甲状腺、淋巴组织、纤维脂肪组织，以及罕见的胸腺组织）区分开来可能具有挑战性。术中细胞学检查（IC）提供了有价值的补充形态学细节。我们单独用IC评估了72个标本（第1组），随后用FS进行解读，以结合IC和FS得出最终解读结果（第2组）。另外105个标本仅通过FS进行评估（第3组）。永久切片诊断被用作“金标准”。第2组的敏感性和特异性均为100%，相比之下，第1组（分别为98%和100%）和第3组（分别为94%和94%）的值较低。在术中会诊评估甲状旁腺部位的组织时，IC是FS的一项有价值的辅助手段。
