Virgilio L A, Williams R J, Klintworth G K
Arch Ophthalmol. 1976 Jan;94(1):101-5. doi: 10.1001/archopht.1976.03910030047012.
Severe progressive ocular enlargement of late onset accompanying chronic uveitis and secondary glaucoma occurred in an 18-year-old man. Electron microscopy of the thin sclera from the unusually large eye (40x40x37 mm) disclosed collagen fibrils with mean widths that exceeded that of controls, but that were within the range of the fibril size typically present in the outer sclera. Thinner fibrils that normally occur particularly within the inner sclera were conspicuously absent. Morphologic observations on corneal and cutaneous collagen from the patient were unremarkable. No abnormality was detected on chemical analysis of cutaneous collagen. The abnormal morphologic pattern of the scleral collagen is interpreted as a probable arrest in scleral collagen synthesis.
一名18岁男性出现伴有慢性葡萄膜炎和继发性青光眼的迟发性严重进行性眼球增大。对这只异常大的眼睛（40×40×37毫米）的薄巩膜进行电子显微镜检查发现，胶原纤维的平均宽度超过了对照组，但仍在通常存在于巩膜外层的纤维大小范围内。正常情况下特别是在巩膜内层出现的较细纤维明显缺失。对该患者角膜和皮肤胶原的形态学观察无异常。皮肤胶原的化学分析未检测到异常。巩膜胶原的异常形态模式被解释为巩膜胶原合成可能停滞。
